1888: Ferruccio Biondi Santi, who is said to have resided on the Castiglion del Bosco Estate, concentrates on an isolated Sangiovese clone to produce the first bottles of what will become Tuscany's most prestigious red wine denomination, Brunello di Montalcino.
1960s: There are only a handful of Brunello di Montalcino wine producers.
1967: Castiglion del Bosco becomes one of the founding members of the Consorzio del Vino Brunello di Montalcino. The organization is created as a voluntary association of producers who regulate and control the quality of Brunello production. Brunello is among the first Italian wines to be granted the titles DOC (Controlled Denomination of Origin) and DOCG (Controlled and Guaranteed Denomination of Origin).
1972: The Val d'Orcia is considered a site of 'outstanding universal value' by the World Heritage Committee according to Article 1 of the 1972 World Heritage Convention, making Castiglion del Bosco a World Heritage Site.
1975: The number of Brunello di Montalcino producers increases to 25 vintners producing approximately 70,000 cases.
1995: According to the Consorzio del Vino Brunello di Montalcino, 120 producers made 300,000 cases of wine in 1995. Today, there are well over 200 producers in the Consorzio producing more than 500,000 cases of Brunello.
1996: The Val d'Orcia Artistic, Natural and Cultural Park is founded. The Park, which encompasses the Castiglion del Bosco property, is an Area Naturale Protetta di Interesse Locale focused on increasing awareness of cultural and environmental heritage, as well as manufacturing and marketing of local products.